Lili Elbe is an opera in two acts based on the life of Lili Elbe (1882–1931) who before transition was known as the acclaimed Danish landscape painter Einar Wegener. Lili was happily married to Gerda Wegener (1886–1940), herself an important artist considered the Danish pioneer of Art Deco and a sought-after portraitist.
As a pioneer of gender affirmation surgery, Lili endures the terrible pains and dangers of the more limited and experimental medical science of her time, ultimately dying from complications after a second surgery. During this journey both Lili and Gerda find temporary love in different quarters. Lili and Gerda, together at the end, declare their great and everlasting love for each other, which has never altered.